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SARS-CoV-2 Spike antibody (B.1.1.7 - alpha, P681H)

Reactivity: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Alpha ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6992311
  • Target See all SARS-CoV-2 Spike Antibodies
    SARS-CoV-2 Spike
    Binding Specificity
    • 44
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    B.1.1.7 - alpha, P681H
    Reactivity
    • 84
    • 10
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Alpha
    Host
    • 32
    • 30
    • 21
    • 2
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 56
    • 18
    • 12
    Polyclonal
    Conjugate
    • 77
    • 5
    • 3
    • 1
    This SARS-CoV-2 Spike antibody is un-conjugated
    Application
    • 64
    • 31
    • 27
    • 10
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Purification
    SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody is affinity chromatography purified via peptide column.
    Immunogen
    Anti-SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody was raised against a peptide corresponding to 12 amino acids near the center of SARS-CoV-2 UK variant (B.1.1.7) Spike protein. The immunogen is located within 650-700 amino acids of SARS-CoV-2 UK variant (B.1.1.7) Spike protein.
    Isotype
    IgG
    Top Product
    Discover our top product SARS-CoV-2 Spike Primary Antibody
  • Application Notes
    WB: 1 μ,g/mL. Antibody validated: Western Blot in human samples. Anti-SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody can specifically detect SARS-CoV-2 UK Variant (B.1.1.7) Spike S1 protein, but not SARS-CoV-2 WT Spike S1 protein by ELISA. It can also detect mutant peptide (681H), but not WT peptide (681P). All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SARS-CoV-2 Spike
    Abstract
    SARS-CoV-2 Spike Products
    Synonyms
    E2 antibody, E2 glycoprotein precursor antibody, Surface Glycoprotein antibody, S antibody
    Target Type
    Viral Protein
    Background

    In September of 2020 a new lineage of SARS-CoV-2, known as B.1.1.7, was discovered in the United Kingdom. This lineage was found to have developed 14 lineage-specific amino acid replacements and 3 deletions prior to its discovery. The transmission of UK variant (B.1.1.7 lineage) was increased at least 50 % . Increased severity and higher death rate were also found in UK variant. UK variant will not affect the effectiveness of COVID19 vaccine. One of the mutations associated with this lineage is a N501Y in the spike protein of the virus. It is believed that this mutation is able to increase the spike protein's affinity for the host ACE2 receptor and it has been associated with increased infectivity and virulence. B.1.1.7 viruses have also been shown to have a P681H in the cleavage site of spike protein. This location is one of the residues that make up the furin cleavage site between S1 and S2 in spike protein.

    Gene ID
    43740568
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