Shootin-1 (SHTN1) antibody
-
- Target See all Shootin-1 (SHTN1) Antibodies
- Shootin-1 (SHTN1)
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- Un-conjugated
-
Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Characteristics
- Polyclonal Antibody
- Purification
- Antigen affinity purification
- Immunogen
- Synthetic peptide of human SHTN1
- Isotype
- IgG
- Top Product
- Discover our top product SHTN1 Primary Antibody
-
anti-Shootin-1 (SHTN1) (AA 21-130) antibody
SHTN1 Reactivity: Human, Rat WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC Host: Rabbit Polyclonal unconjugated
anti-Shootin-1 (SHTN1) (N-Term) antibodySHTN1 Reactivity: Human, Rat, Mouse, Horse, Monkey WB Host: Rabbit Polyclonal unconjugated
-
- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:100, ELISA 1:5000-1:10000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.78 mg/mL
- Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- Shootin-1 (SHTN1)
- Alternative Name
- SHTN1 (SHTN1 Products)
- Synonyms
- Kiaa1598 antibody, Shootin1 antibody, mKIAA1598 antibody, shootin 1 antibody, SHTN1 antibody, Shtn1 antibody
- Background
- Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
- Molecular Weight
-
Observed_MW: Refer to figures
Calculated_MW: 72 kDa
- UniProt
- A0MZ66
-
