Meprin B antibody

Catalog No. ABIN7255141

Product Details anti-Meprin B Antibody

Target: Meprin B (MEP1B) (Meprin A, beta (MEP1B))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Meprin B antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human MEP1B (NP_005916.2).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Meprin B

Target: Meprin B (MEP1B) (Meprin A, beta (MEP1B))

Alternative Name: MEP1B (MEP1B Products)

Synonyms: MEP1B antibody, si:ch211-191a24.6 antibody, zgc:153272 antibody, Mep-1b antibody, meprin A subunit beta antibody, meprin A, beta antibody, meprin 1 beta antibody, MEP1B antibody, LOC100031050 antibody, mep1b antibody, LOC100545010 antibody, Mep1b antibody

Background: Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.

Molecular Weight:

Observed_MW: 105 kDa

Calculated_MW: 79 kDa

Gene ID: 4225

UniProt: Q16820