ZNF828 antibody

Catalog No. ABIN7255730

Product Details anti-ZNF828 Antibody

Target: ZNF828 (Zinc Finger Protein 828 (ZNF828))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF828 antibody is un-conjugated

Application: Immunofluorescence (IF)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human CHAMP1 (NP_115812.1).

Isotype: IgG

Application Details

Application Notes: IF 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ZNF828

Target: ZNF828 (Zinc Finger Protein 828 (ZNF828))

Alternative Name: CHAMP1 (ZNF828 Products)

Synonyms: ZNF828 antibody, C13orf8 antibody, CAMP antibody, CHAMP antibody, AA675043 antibody, AI116001 antibody, D8Ertd457e antibody, D8Ertd569e antibody, Zfp828 antibody, Znf828 antibody, mKIAA1802 antibody, chromosome alignment maintaining phosphoprotein 1 antibody, CHAMP1 antibody, Champ1 antibody

Background: CHAMP1 (chromosome alignment maintaining phosphoprotein 1), also known as ZNF828 or C13orf8, is a 812 amino acid protein containing one C2H2-type zinc finger. CHAMP1 is required for the proper alignment of chromosomes during metaphase, undergoing CDK1-dependent phosphorylation at multiple sites during mitosis. The phosphorylation counteracts the negative chromosomal alignment regulation of the zinc-finger domain of CHAMP1. One region of CHAMP1, the FPE region, is responsible for spindle and kinetochore localization, which is essential for proper chromosome alignment. CHAMP1 interacts with MAD2L2, PGOZ, CBX1, CBX3 and CBX5, and may recruit CENPE and CENPF to the kinetochore. The CHAMP1 gene is located on chromosome 13 and is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat and chicken.

Gene ID: 283489

UniProt: Q96JM3

Pathways: Maintenance of Protein Location