ABCC5 antibody

Catalog No. ABIN7255846

Product Details anti-ABCC5 Antibody

Target: ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCC5 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: A synthetic peptide of human ABCC5 (NP_005679.2).

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ABCC5

Target: ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))

Alternative Name: ABCC5 (ABCC5 Products)

Synonyms: ABC33 antibody, EST277145 antibody, MOAT-C antibody, MOATC antibody, MRP5 antibody, SMRP antibody, pABC11 antibody, 2900011L11Rik antibody, AI132311 antibody, Abcc5a antibody, Abcc5b antibody, Mrp5 antibody, abc33 antibody, abcc5 antibody, moat-c antibody, moatc antibody, mrp5 antibody, pabc11 antibody, smrp antibody, ATP binding cassette subfamily C member 5 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 5 antibody, ATP binding cassette subfamily C member 5 L homeolog antibody, ABCC5 antibody, Abcc5 antibody, abcc5.L antibody

Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants.

Gene ID: 10057

UniProt: O15440

Pathways: Glycosaminoglycan Metabolic Process