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TDG antibody

TDG Reactivity: Human, Mouse, Rat IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7256880
  • Target See all TDG Antibodies
    TDG (Thymine-DNA Glycosylase (TDG))
    Reactivity
    • 46
    • 19
    • 11
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 37
    • 10
    Rabbit
    Clonality
    • 40
    • 8
    Polyclonal
    Conjugate
    • 41
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TDG antibody is un-conjugated
    Application
    • 38
    • 11
    • 10
    • 8
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Immunofluorescence (IF)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human TDG (NP_003202.3).
    Isotype
    IgG
    Top Product
    Discover our top product TDG Primary Antibody
  • Application Notes
    IF 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    TDG (Thymine-DNA Glycosylase (TDG))
    Alternative Name
    TDG (TDG Products)
    Synonyms
    5-MCDG antibody, wu:fb44b11 antibody, zgc:110622 antibody, MGC82456 antibody, MGC89441 antibody, E130317C12Rik antibody, JZA-3 antibody, Jza1 antibody, hTDG antibody, thymine DNA glycosylase antibody, thymine DNA glycosylase, tandem duplicate 1 antibody, putative g/t mismatch-specific thymine DNA glycosylase antibody, G/T mismatch-specific thymine DNA glycosylase antibody, thymine DNA glycosylase S homeolog antibody, thymine-DNA glycosylase antibody, TDG antibody, tdg.1 antibody, Smp_149220 antibody, Tsp_05734 antibody, tdg.S antibody, tdg antibody, Tdg antibody
    Background
    The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
    Gene ID
    6996
    UniProt
    Q13569
    Pathways
    DNA Damage Repair, Chromatin Binding
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