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BRCA2 antibody
BRCA2
Reactivity: Human, Rat
IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-BRCA2 Antibody
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Target
See all BRCA2 Antibodies
BRCA2
(Breast Cancer 2, Early Onset (BRCA2))
Reactivity
All reactivities for BRCA2 antibodies
Human, Rat
Host
All hosts for BRCA2 antibodies
Rabbit
Clonality
All clonalities for BRCA2 antibodies
Polyclonal
Conjugate
All conjugates for BRCA2 antibodies
This BRCA2 antibody is un-conjugated
Application
All applications for BRCA2 antibodies
Immunofluorescence (IF)
Characteristics
Polyclonal Antibody
Purification
Affinity purification
Immunogen
Recombinant fusion protein of human BRCA2 (NP_000050.2).
Isotype
IgG
Top Product
Discover our top product BRCA2 Primary Antibody
Alternatives
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Application Details
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Application Notes
IF 1:50-1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for BRCA2
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Target
BRCA2
(Breast Cancer 2, Early Onset (BRCA2))
Alternative Name
BRCA2 (BRCA2 Products )
Synonyms
BRCC2 antibody, BROVCA2 antibody, FACD antibody, FAD antibody, FAD1 antibody, FANCB antibody, FANCD antibody, FANCD1 antibody, GLM3 antibody, PNCA2 antibody, 30169 antibody, BcDNA:SD25109 antibody, CG13583 antibody, CG13584 antibody, CG30169 antibody, Dmel\\CG30169 antibody, brca2 antibody, dmbrca2 antibody, fancd1 antibody, BRCA2 antibody, brcc2 antibody, brovca2 antibody, facd antibody, fad antibody, fad1 antibody, fancb antibody, AI256696 antibody, AW045498 antibody, Fancd1 antibody, RAB163 antibody, BRCA2, DNA repair associated antibody, Breast cancer 2, early onset homolog antibody, breast cancer 2, early onset antibody, BRCA2 antibody, Brca2 antibody, brca2 antibody, LOC584780 antibody
Background
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
Gene ID
675
UniProt
P51587
Pathways
DNA Damage Repair , M Phase , Maintenance of Protein Location
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