PDP antibody

Catalog No. ABIN7262136

Product Details anti-PDP Antibody

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDP antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human PDP1 (NP_060914.2).

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PDP

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Alternative Name: PDP1 (PDP Products)

Synonyms: 153332_at antibody, CG12151 antibody, Dmel\\CG12151 antibody, PDP antibody, pdp antibody, PDH antibody, PDPC antibody, PPM2C antibody, Gm1024 antibody, Ppm2c antibody, im:7157162 antibody, zgc:174908 antibody, pdp1 antibody, ppm2c antibody, Pyruvate dehydrogenase phosphatase antibody, pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial antibody, pyruvate dehyrogenase phosphatase catalytic subunit 1 antibody, pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog antibody, Pdp antibody, LOC413080 antibody, PDP1 antibody, Pdp1 antibody, pdp1 antibody, pdp1.L antibody

Background: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID: 54704

UniProt: Q9P0J1