AW208791 antibody, Mint-3 antibody, X11gamma antibody, lin-10 antibody, mint3 antibody, MGC:15815 antibody, X11L2 antibody, Mint3 antibody, amyloid beta precursor protein binding family A member 3 antibody, amyloid beta (A4) precursor protein-binding, family A, member 3 antibody, APBA3 antibody, Apba3 antibody
Background
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer's disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the Beta-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 (Mint 3).