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TBC1D7 antibody

TBC1D7 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7075849
  • Target See all TBC1D7 Antibodies
    TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))
    Reactivity
    • 25
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 23
    • 2
    Rabbit
    Clonality
    • 25
    Polyclonal
    Conjugate
    • 11
    • 4
    • 3
    • 3
    • 2
    • 2
    This TBC1D7 antibody is un-conjugated
    Application
    • 20
    • 16
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Cross-Reactivity
    Human, Rat
    Purification
    Affinity purification
    Immunogen
    Recombinant protein corresponding to Mouse TBC1D7
    Top Product
    Discover our top product TBC1D7 Primary Antibody
  • Application Notes
    WB (H,M,R) 1: 500- 1: 1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, pH 7.4, 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Target
    TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))
    Alternative Name
    TBC1D7 (TBC1D7 Products)
    Synonyms
    PIG51 antibody, TBC7 antibody, dJ257A7.3 antibody, 2610009C09Rik antibody, TBC1 domain family member 7 antibody, TBC1 domain family, member 7 antibody, TBC1D7 antibody, Tbc1d7 antibody
    Background
    TBC1 domain family member 7 (TBC1D7, TBC7) belongs to a family of TBC (Tre-2/Bub2/Cdc16) containing proteins that function as GTPase-activating proteins (GAPs) . TBC1D7 was initially identified as a novel binding protein within the TSC1-TSC2 complex, where it was thought to associate with TSC1 . Additional research indicates that TBC1D7 is a third subunit of the TSC1-TSC2 complex that possesses Rheb-GAP activity and signals upstream of mTORC1. Knockdown of TBC1D7 limits the association between TSC1 and TSC2, resulting in reduced Rheb-GAP activity and increased mTORC1 signaling . Mutations in the corresponding TBC1D7 gene result in increased mTORC1 signaling, delayed autophagy, and are associated with intellectual disability (ID) and macrocrania.
    Molecular Weight
    36 kDa
    Gene ID
    67046
    NCBI Accession
    NP_001239568
    UniProt
    Q9D0K0
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