WEE2 antibody

Catalog No. ABIN7076224

Product Details anti-WEE2 Antibody

Target: WEE2 (WEE1 Homolog 2 (S. Pombe) (WEE2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WEE2 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse WEE2

Application Details

Application Notes: WB (H) 1:300-1:600

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for WEE2

Target: WEE2 (WEE1 Homolog 2 (S. Pombe) (WEE2))

Alternative Name: WEE2 (WEE2 Products)

Synonyms: Xe-wee1 antibody, wee1 antibody, wee1-b antibody, wee1a antibody, wee1b antibody, wee2-b antibody, xwee1 antibody, xwee2 antibody, WEE1B antibody, Gm1065 antibody, Wee1B antibody, WEE2 antibody, im:5913035 antibody, si:ch211-238n5.5 antibody, wu:fi13b10 antibody, zgc:123074 antibody, WEE1 homolog 2 antibody, WEE1 homolog 2 (S. pombe) antibody, wee2 antibody, WEE2 antibody, Wee2 antibody

Background: WEE2, also named as WEE1B, belongs to the protein kinase superfamily. Ser/Thr protein kinase family and WEE1 subfamily. It phosphorylates and inhibits CDK1. WEE2 may act as a negative regulator of entry into mitosis (G2 to M transition). WEE2 is conserved from yeast to humans. The aim of the present study was to determine the spatiotemporal expression pattern and the function of WEE2 during oocyte maturation in a nonhuman primate species, the rhesus macaque. Taking the long double-stranded RNA-mediated RNA interference approach, down-regulation of WEE2 led to meiotic resumption in a subset of GV oocytes even in the presence of a phosphodiesterase 3 inhibitor. Overexpression of WEE2 delays the reentry of oocytes into meiosis in both mice and monkeys. WEE2 is a conserved oocyte-specific meiosis inhibitor that functions downstream of cAMP in nonhuman primates.

Molecular Weight: 62 kDa

Gene ID: 381759

UniProt: Q66JT0

Pathways: M Phase