EDNRB antibody (AA 378-442)

Catalog No. ABIN705116

Product Details anti-EDNRB Antibody

Target: EDNRB (Endothelin Receptor Type B (EDNRB))

Binding Specificity: AA 378-442

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EDNRB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Endolin B Receptor

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-EDNRB antibody (ABIN705116)

Prayitnaningsih, Sujuti, Effendi, Abdullah, Anandita, Yohana, Permatasari, Widodo: "Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats." in: International journal of ophthalmology, Vol. 9, Issue 11, pp. 1568-1577, (2016) (PubMed).

Target Details for EDNRB

Target: EDNRB (Endothelin Receptor Type B (EDNRB))

Alternative Name: ETBR/Endothelin B Receptor (EDNRB Products)

Synonyms: ABCDS antibody, ET-B antibody, ET-BR antibody, ETB antibody, ETBR antibody, ETRB antibody, HSCR antibody, HSCR2 antibody, WS4A antibody, Ednra antibody, Etb antibody, ETR-b antibody, ETb antibody, Sox10m1 antibody, EDNRB antibody, abcds antibody, etb antibody, etrb antibody, hscr antibody, hscr2 antibody, endothelin receptor type B antibody, EDNRB antibody, Ednrb antibody, ednrb antibody

Background:

Synonyms: ABCDS, Ednra, Ednrb, EDNRB_HUMAN, Endothelin B receptor, Endothelin B receptor precursor, Endothelin receptor Non selective type, Endothelin receptor non-selective type, Endothelin receptor type B, ET B, ET-B, ET-BR, ETB, ETRB, Hirschsprung disease 2, HSCR, HSCR2, EDNRB, HSCR, WS4A.

Background: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Gene ID: 1910

UniProt: P24530

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process