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CRBN antibody

CRBN Reactivity: Human, Mouse, Rat WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7112626
  • Target See all CRBN Antibodies
    CRBN (Cereblon (CRBN))
    Reactivity
    • 20
    • 19
    • 11
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 24
    • 2
    Rabbit
    Clonality
    • 26
    Polyclonal
    Conjugate
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CRBN antibody is un-conjugated
    Application
    • 13
    • 13
    • 11
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    cereblon
    Isotype
    IgG
    Top Product
    Discover our top product CRBN Primary Antibody
  • Application Notes
    WB: 1:500-1:2000, IHC: 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    CRBN (Cereblon (CRBN))
    Alternative Name
    CRBN (CRBN Products)
    Synonyms
    zgc:92404 antibody, mrt2a antibody, F3N11.21 antibody, MRT2 antibody, MRT2A antibody, 2610203G15Rik antibody, 2900045O07Rik antibody, AF229032 antibody, AW108261 antibody, piL antibody, cereblon antibody, ATP-dependent protease La (LON) domain protein antibody, crbn antibody, CRBN antibody, AT2G25740 antibody, Crbn antibody
    Background
    Synonyms:cereblon, CRBN, MRT2A, Protein cereblon Background:Substrate recognition component of a DCX(DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.
    Molecular Weight
    53 kDa
    Gene ID
    51185
    UniProt
    Q96SW2
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