IFIT1 antibody

Catalog No. ABIN7115381

Product Details anti-IFIT1 Antibody

Target: IFIT1 (Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFIT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: interferon-induced protein with tetratricopeptide repeats 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for IFIT1

Target: IFIT1 (Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1))

Alternative Name: IFIT1 (IFIT1 Products)

Synonyms: C56 antibody, G10P1 antibody, IFI-56 antibody, IFI-56K antibody, IFI56 antibody, IFIT-1 antibody, IFNAI1 antibody, ISG56 antibody, P56 antibody, RNM561 antibody, Ifi56 antibody, Garg16 antibody, DKFZp469C2331 antibody, interferon induced protein with tetratricopeptide repeats 1 antibody, interferon-induced protein with tetratricopeptide repeats 1 antibody, IFIT1 antibody, Ifit1 antibody, LOC488947 antibody, ifit1 antibody, LOC100058990 antibody, LOC100139670 antibody, LOC100475782 antibody

Background: Synonyms:G10P1, GARG 16, IFI 56, IFI 56K, IFI56, IFIT 1, IFIT1, IFNAI1, ISG56, RNM561 Background:Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group(PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.

Molecular Weight: 55 kDa

Gene ID: 3434

UniProt: P09914

Pathways: Hepatitis C