MAP4K6 antibody

Catalog No. ABIN7116324

Product Details anti-MAP4K6 Antibody

Target: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP4K6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: misshapen-like kinase 1(zebrafish)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for MAP4K6

Target: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Alternative Name: MINK1 (MINK1 Products)

Synonyms: MINK1 antibody, MINK antibody, B55 antibody, MAP4K6 antibody, YSK2 antibody, ZC3 antibody, hMINK antibody, hMINKbeta antibody, MEKKK 6 antibody, Map4k6 antibody, RP23-122P1.6 antibody, Ysk2 antibody, misshapen like kinase 1 antibody, misshapen-like kinase 1 antibody, misshapen-like kinase 1 (zebrafish) antibody, MINK1 antibody, Mink1 antibody

Background: Synonyms:B55, MAP4K6, Background:Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Molecular Weight: 150 kDa

Gene ID: 50488

UniProt: Q8N4C8

Pathways: Synaptic Membrane