MMP2 antibody (Matrix Metalloproteinase 2) (AA 409-434)

Details for Product anti-MMP2 Antibody No. ABIN707426, Supplier: Log in to see
Antigen
  • 2-MMP
  • CG1794
  • DM2-MMP
  • Dm2-MMP
  • Dmel\\CG1794
  • MMP2
  • anon-WO0118547.84
  • dm-2MMP
  • dmmp2
  • l(2)02353
  • mmp2
  • wu:fa99h12
  • wu:fk89d01
  • fgmmp-2
  • Mmp-2
  • LOC100135793
  • Clg4a
  • GelA
  • MMP-2
  • CLG4
  • CLG4A
  • MMP-II
  • MONA
  • TBE-1
  • matrix metallopeptidase 2
  • Matrix metalloproteinase 2
  • matrix metalloproteinase 2
  • matrix metalloproteinase-2
  • MMP2
  • Mmp2
  • mmp2
  • LOC657982
  • LOC100135793
Alternatives
anti-Rat (Rattus) MMP2 antibody for Immunoprecipitation
Epitope
AA 409-434
21
20
18
16
15
14
12
10
10
10
8
8
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6
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
395
182
171
29
16
15
13
11
7
6
6
5
4
2
2
2
2
2
1
1
1
Host
Rabbit
247
177
2
2
1
1
Clonality
Polyclonal
Conjugate
This MMP2 antibody is un-conjugated
20
17
15
8
8
6
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5
5
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4
4
4
4
3
3
3
3
3
3
3
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3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
325
149
113
108
88
72
63
60
54
38
19
6
5
2
1
1
Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide derived from human MMP-2
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others MMP2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Mmp-2 (MMP2 Antibody Abstract)
Background

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Subcellular location: Cytoplasm, Nucleus, Secreted, Mitochondrion, Membrane bound

Synonyms: CLG4, MONA, CLG4A, MMP-2, TBE-1, MMP-II, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP2

Gene ID 4313
UniProt P08253
Pathways Activation of Innate immune Response
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 409-434) antibody (ABIN707426) Rabbit heart lysates probed with Anti-MMP-2 Polyclonal Antibody, Unconjugated (ABIN70...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 409-434) antibody (ABIN707426) Formalin-fixed and paraffin embedded human laryngeal carcinoma labeled with Anti-MMP-...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 409-434) antibody (ABIN707426) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-MMP-2 Pol...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 409-434) antibody (ABIN707426) Paraformaldehyde-fixed, paraffin embedded rat bladder tissue, Antigen retrieval by bo...
Product cited in: Wang, Nikhil, Viccaro, Chang, White, Shah: "Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer." in: BMC biology, Vol. 15, Issue 1, pp. 10, 2017 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Human).

Liu, Chi, Lu, Zhang, Yamakawa: "Reversion-inducing-cysteine-rich Protein with Kazal Motif Is Involved in Intimal Hyperplasia in Carotid Arteries: A New Insight in the Prevention of Restenosis after Vascular Angioplasty." in: Annals of vascular surgery, Vol. 29, Issue 6, pp. 1293-9, 2015 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Human).

Cavdar, Ozbal, Celik, Ergur, Guneli, Ural, Camsari, Guner: "The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, Vol. 89, Issue 4, pp. 304-14, 2014 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)). Further details: Sample: kidney

Fan, Han, Zhu, Zhang, Zhu: "Ultrasensitive photoelectrochemical immunoassay for matrix metalloproteinase-2 detection based on CdS:Mn/CdTe cosensitized TiO2 nanotubes and signal amplification of SiO2@Ab2 conjugates." in: Analytical chemistry, Vol. 86, Issue 24, pp. 12398-405, 2014 (PubMed).

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