ERAS antibody (AA 20-120)

Catalog No. ABIN708161

Product Details anti-ERAS Antibody

Target: ERAS (ES cell expressed Ras (ERAS))

Binding Specificity: AA 20-120

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERAS antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ERAS/HRAS2

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ERAS

Target: ERAS (ES cell expressed Ras (ERAS))

Alternative Name: ERAS/HRAS2 (ERAS Products)

Synonyms: HRAS2 antibody, HRASP antibody, HRasp antibody, Ha-Ras2 antibody, ecat5 antibody, ES cell expressed Ras antibody, ES cell-expressed Ras antibody, ERAS antibody, Eras antibody

Background:

Synonyms: E ras, E-Ras, ecat5, Embryonic stem cell expressed Ras, Embryonic stem cell-expressed Ras, Eras, ES cell expressed Ras, GTPase ERas, Ha-Ras2, HRAS2, HRASP, MGC126691, MGC126693, OTTHUMP00000065857, RASE_HUMAN, Small GTPase protein E Ras, v Ha ras Harvey rat sarcoma viral oncogene homolog pseudogene, v Ha ras Harvey rat sarcoma viral oncogene homolog 2.

Background: ERAS belongs to the small GTPase superfamily. Ras family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. The ERas gene is expressed in embryonic stem (ES) cells and promotes their in vitro proliferation and tumorigenicity. ERas-null ES cells maintain pluripotency but show significantly reduced growth and tumorigenicity, which are rescued by expression of ERas complementary DNA or by activated phosphatidylinositol-3-OH kinase.

Gene ID: 3266