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Recombinant LRRK2 antibody

LRRK2 Reactivity: Human ELISA, IHC Host: Rabbit Monoclonal 4E9 unconjugated Recombinant Antibody
Catalog No. ABIN7321713
  • Target See all LRRK2 Antibodies
    LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 18
    • 8
    • 1
    Human
    Host
    • 15
    • 3
    Rabbit
    Clonality
    • 15
    • 3
    Monoclonal
    Conjugate
    • 15
    • 1
    • 1
    • 1
    This LRRK2 antibody is un-conjugated
    Application
    • 13
    • 8
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    Affinity-chromatography
    Immunogen
    A synthesized peptide derived from human LRRK2
    Clone
    4E9
    Isotype
    IgG
    Top Product
    Discover our top product LRRK2 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))
    Alternative Name
    LRRK2 (LRRK2 Products)
    Synonyms
    LRRK2 antibody, AURA17 antibody, DARDARIN antibody, PARK8 antibody, RIPK7 antibody, ROCO2 antibody, 4921513O20Rik antibody, 9330188B09Rik antibody, AW561911 antibody, D630001M17Rik antibody, Gm927 antibody, cI-46 antibody, leucine-rich repeat kinase 2 antibody, leucine rich repeat kinase 2 antibody, lrrk2 antibody, LRRK2 antibody, Lrrk2 antibody
    Background

    Background: Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH , and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.

    Aliases: Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin), LRRK2, PARK8

    UniProt
    Q5S007
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
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