PSMD1 antibody (Regulatory Subunit 10) (HRP)

Catalog No. ABIN7142201

Product Details anti-PSMD1 Antibody (HRP)

Target: PSMD1 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1))

Binding Specificity: AA 1-226, Regulatory Subunit 10

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMD1 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 26S proteasome non-ATPase regulatory subunit 10 protein (1-226AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PSMD1

Target: PSMD1 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 1 (PSMD1))

Alternative Name: PSMD1 (PSMD1 Products)

Synonyms: P112 antibody, Rpn2 antibody, S1 antibody, 2410026J11Rik antibody, zgc:55818 antibody, psmd1 antibody, proteasome 26S subunit, non-ATPase 1 antibody, proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 antibody, proteasome 26S subunit, non-ATPase 1 L homeolog antibody, PSMD1 antibody, Psmd1 antibody, psmd1 antibody, psmd1.L antibody

Background:

Background: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.

Aliases: 26S proteasome non-ATPase regulatory subunit 10 antibody, 26S proteasome regulatory subunit p28 antibody, Ankyrin repeat protein antibody, dJ889N15.2 antibody, Gankyrin antibody, Hepatocellular carcinoma-associated protein p28 II antibody, p28 antibody, p28(GANK) antibody, Proteasome (prosome, macropain) 26S subunit, non ATPase, 10 antibody, Proteasome 26S S10 antibody, PSD10_HUMAN antibody, Psmd10 antibody

UniProt: O75832

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway