HSD3B7 antibody (AA 131-197) (Biotin)

Catalog No. ABIN7142281

Product Details anti-HSD3B7 Antibody (Biotin)

Target: HSD3B7 (Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 7 (HSD3B7))

Binding Specificity: AA 131-197

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD3B7 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 3 beta-hydroxysteroid dehydrogenase type 7 protein (131-197AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HSD3B7

Target: HSD3B7 (Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 7 (HSD3B7))

Alternative Name: HSD3B7 (HSD3B7 Products)

Synonyms: CBAS1 antibody, PFIC4 antibody, SDR11E3 antibody, AI195443 antibody, BB098564 antibody, Cca2 antibody, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 antibody, HSD3B7 antibody, Hsd3b7 antibody

Background:

Background: The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.

Aliases: HSD3B73 beta-hydroxysteroid dehydrogenase type 7 antibody, 3 beta-hydroxysteroid dehydrogenase type VII antibody, 3-beta-HSD VII antibody, 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase antibody, C(27) 3-beta-HSD antibody, EC 1.1.1.- antibody, Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase antibody, EC 1.1.1.181 antibody

UniProt: Q9H2F3