NR1H4 antibody (AA 1-476) (Biotin)

Catalog No. ABIN7145585

Product Details anti-NR1H4 Antibody (Biotin)

Target: NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

Binding Specificity: AA 1-476

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR1H4 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Bile acid receptor protein (1-476AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NR1H4

Target: NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

Alternative Name: NR1H4 (NR1H4 Products)

Synonyms: zgc:110190 antibody, zgc:92742 antibody, NR1H4 antibody, BAR antibody, FXR antibody, HRR-1 antibody, HRR1 antibody, RIP14 antibody, AI957360 antibody, Fxr antibody, Rxrip14 antibody, nuclear receptor subfamily 1, group H, member 5 S homeolog antibody, nuclear receptor subfamily 1, group H, member 4 antibody, nuclear receptor subfamily 1 group H member 4 antibody, nr1h5.S antibody, nr1h4 antibody, NR1H4 antibody, Nr1h4 antibody

Background:

Background: Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.

Aliases: BAR antibody, Bile acid receptor antibody, Farnesoid X activated receptor antibody, Farnesoid X receptor antibody, Farnesoid X-activated receptor antibody, Farnesol receptor HRR 1 antibody, Farnesol receptor HRR-1 antibody, Farnesol receptor HRR1 antibody, FXR antibody, HRR 1 antibody, HRR1 antibody, NR1H4 antibody, NR1H4_HUMAN antibody, Nuclear receptor subfamily 1 group H member 4 antibody, Retinoid X receptor interacting protein 14 antibody, Retinoid X receptor-interacting protein 14 antibody, RIP 14 antibody, RIP14 antibody, RXR interacting protein 14 antibody, RXR-interacting protein 14 antibody

UniProt: Q96RI1

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process