DACT1 antibody (AA 410-525)

Catalog No. ABIN7149488

Product Details anti-DACT1 Antibody

Target: DACT1 (Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1))

Binding Specificity: AA 410-525

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DACT1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Dapper homolog 1 protein (410-525AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DACT1

Target: DACT1 (Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1))

Alternative Name: DACT1 (DACT1 Products)

Synonyms: XDpr antibody, dpr1 antibody, frodo antibody, hdpr1 antibody, Dapper antibody, thyex3 antibody, dapper1 antibody, MGC89695 antibody, frd1 antibody, frodo1 antibody, 4921528D17Rik antibody, AI115603 antibody, DAPPER antibody, DAPPER1 antibody, FRODO antibody, Frd1 antibody, Frodo1 antibody, MDpr1 antibody, MTNG3 antibody, THYEX3 antibody, DPR1 antibody, HDPR1 antibody, DACT1 antibody, RGD1564008 antibody, XDpr1a antibody, dact1 antibody, dpr antibody, XDpr1b antibody, dishevelled-binding antagonist of beta-catenin 1 antibody, dishevelled binding antagonist of beta catenin 1 antibody, dishevelled-binding antagonist of beta-catenin 1 L homeolog antibody, dishevelled-binding antagonist of beta-catenin 1 S homeolog antibody, dact1 antibody, Dact1 antibody, DACT1 antibody, dact1.L antibody, dact1.S antibody

Background:

Background: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism, the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2, the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.

Aliases: Dact antibody, dact1 antibody, DACT1_HUMAN antibody, Dapper antagonist of beta catenin homolog 1 antibody, Dapper antagonist of catenin 1 antibody, Dapper antibody, Dapper homolog 1 antibody, DAPPER1 antibody, Dpr antibody, Dpr1 antibody, Frd antibody, Frodo antibody, hDPR1 antibody, Hepatocellular carcinoma novel gene 3 protein antibody, Heptacellular carcinoma novel gene 3 antibody, HNG3 antibody, MTNG3 antibody, Thyex3 antibody

UniProt: Q9NYF0

Pathways: Positive Regulation of fat Cell Differentiation