DYNLL1 antibody (AA 1-89)

Catalog No. ABIN7150882

Product Details anti-DYNLL1 Antibody

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Binding Specificity: AA 1-89

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYNLL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Dynein light chain 1, cytoplasmic protein (1-89AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DYNLL1

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Alternative Name: DYNLL1 (DYNLL1 Products)

Background:

Background: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

Aliases: 8 kDa dynein light chain antibody, 8kDLC antibody, Cytoplasmic dynein light polypeptide antibody, DLC1 antibody, DLC8 antibody, DNCL1 antibody, DNCLC1 antibody, DYL1_HUMAN antibody, Dynein , cytoplasmic, light chain 1 antibody, Dynein light chain 1 cytoplasmic antibody, Dynein light chain 1, cytoplasmic antibody, Dynein light chain LC8 type 1 antibody, Dynein light chain LC8-type 1 antibody, Dynein, cytoplasmic, light polypeptide 1 antibody, Dynein, light chain, LC8-type 1 antibody, DYNLL1 antibody, HDLC1 antibody, LC8 antibody, LC8a antibody, MGC126137 antibody, MGC126138 antibody, MGC72986 antibody, PIN antibody, Protein inhibitor of neuronal nitric oxide synthase antibody, Protein inhibitor of neuronal NOS antibody

UniProt: P63167

Pathways: M Phase, Tube Formation, Positive Regulation of Endopeptidase Activity