HECW1 antibody (AA 751-900) (Biotin)

Catalog No. ABIN7151034

Product Details anti-HECW1 Antibody (Biotin)

Target: HECW1 (HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 1 (HECW1))

Binding Specificity: AA 751-900

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HECW1 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Antigen Affinity purified & Affinity purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase HECW1 protein (751-900AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HECW1

Target: HECW1 (HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 1 (HECW1))

Alternative Name: HECW1 (HECW1 Products)

Synonyms: NEDL1 antibody, 9330116H24Rik antibody, AV273951 antibody, E130207I19Rik antibody, Nedl1 antibody, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 antibody, HECW1 antibody, Hecw1 antibody

Background:

Background: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.

Aliases: C2 and WW domain-containing protein 1 antibody, E3 ubiquitin-protein ligase HECW1 antibody, HECT antibody, HECT type E3 ubiquitin ligase antibody, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 antibody, HECT, C2 and WW domain-containing protein 1 antibody, HECW 1 antibody, Hecw1 antibody, HECW1_HUMAN antibody, hNEDL1 antibody, NEDD4 like ubiquitin protein ligase 1 antibody, NEDD4-like E3 ubiquitin-protein ligase 1 antibody, NEDL1 antibody

UniProt: Q76N89