EIF3I antibody (AA 1-323) (FITC)

Catalog No. ABIN7152164

Product Details anti-EIF3I Antibody (FITC)

Target: EIF3I (Eukaryotic Translation Initiation Factor 3, Subunit I (EIF3I))

Binding Specificity: AA 1-323

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF3I antibody is conjugated to FITC

Application: Please inquire

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Eukaryotic translation initiation factor 3 subunit I protein (1-323AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EIF3I

Target: EIF3I (Eukaryotic Translation Initiation Factor 3, Subunit I (EIF3I))

Alternative Name: EIF3I (EIF3I Products)

Synonyms: EIF3S2 antibody, PRO2242 antibody, TRIP-1 antibody, TRIP1 antibody, eIF3-beta antibody, eIF3-p36 antibody, 36kDa antibody, D4Ertd632e antibody, Eif3s2 antibody, Trip1 antibody, eIF-3-beta antibody, eIF3 p36 antibody, eif3s2 antibody, hm:zehn0464 antibody, wu:fb62b08 antibody, zgc:56211 antibody, zgc:77823 antibody, CaO19.2967 antibody, eIF-3 39 kDa subunit homolog antibody, eIF3i antibody, eif3-beta antibody, eif3-p36 antibody, eif3i antibody, pro2242 antibody, trip-1 antibody, trip1 antibody, eukaryotic translation initiation factor 3 subunit I antibody, eukaryotic translation initiation factor 3, subunit I antibody, Eukaryotic Initiation Factor antibody, Eukaryotic translation initiation factor 3 subunit I antibody, translation initiation factor eIF3 subunit i antibody, eukaryotic translation initiation factor 3 subunit I L homeolog antibody, EIF3I antibody, Eif3i antibody, eif-3.I antibody, eIF3i antibody, eif3i antibody, TIF34 antibody, eif3i.L antibody

Background:

Background: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Aliases: eIF-3-beta antibody, eIF3 beta antibody, eIF3 p36 antibody, eIF3-beta antibody, eIF3-p36 antibody, eIF3i antibody, EIF3I_HUMAN antibody, EIF3S2 antibody, EIF3S2, formerly antibody, Eukaryotic translation initiation factor 3 subunit 2 antibody, Eukaryotic translation initiation factor 3 subunit 2 beta antibody, Eukaryotic translation initiation factor 3 subunit I antibody, eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD antibody, eukaryotic translation initiation factor 3, subunit 2 beta, 36 kDa antibody, eukaryotic translation initiation factor 3, subunit 2, formerly antibody, eukaryotic translation initiation factor 3, subunit I antibody, Predicted protein of HQ2242 antibody, PRO2242 antibody, TGF beta receptor interacting protein 1 antibody, TGF-beta receptor-interacting protein 1 antibody, TGFbeta receptor interacting protein 1 antibody, TGFbeta receptor-interacting protein 1 antibody, TRIP 1 antibody, TRIP-1 antibody, TRIP1 antibody

UniProt: Q13347

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Ribonucleoprotein Complex Subunit Organization, Synthesis of DNA