APH1A antibody (AA 90-118) (Biotin)

Catalog No. ABIN7153560

Product Details anti-APH1A Antibody (Biotin)

Target: APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))

Binding Specificity: AA 90-118

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APH1A antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Gamma-secretase subunit APH-1A protein (90-118AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for APH1A

Target: APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))

Alternative Name: APH1A (APH1A Products)

Synonyms: 6530402N02Rik antibody, APH-1 antibody, APH-1A antibody, CGI-78 antibody, RGD1311546 antibody, APH-1a antibody, aph-1 homolog A, gamma-secretase subunit antibody, aph-1 homolog A, gamma secretase subunit L homeolog antibody, aph-1 homolog A, gamma secretase subunit antibody, anterior pharynx defective 1 homolog A (C. elegans) antibody, aph1 homolog A, gamma secretase subunit antibody, acylamino-acid-releasing enzyme-like antibody, APH1A antibody, aph1a.L antibody, Aph1a antibody, LOC100219182 antibody

Background:

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

Aliases: 6530402N02Rik antibody, AL138795.3 antibody, Anterior Pharynx Defective 1 antibody, Anterior pharynx defective 1 homolog A antibody, APH 1A antibody, Aph 1alpha antibody, APH-1a antibody, Aph-1alpha antibody, Aph1a antibody, APH1A gamma secretase subunit antibody, APH1A_HUMAN antibody, CGI 78 antibody, CGI78 antibody, Gamma secretase subunit APH 1A antibody, Gamma Secretase Subunit APH1a antibody, Gamma-secretase subunit APH-1A antibody, Likely ortholog of C. elegans anterior pharynx defective 1A antibody, Presenilin Stabilization Factor antibody, Presenilin-stabilization factor antibody, PSF antibody, UNQ579/PRO1141 antibody

UniProt: Q96BI3

Pathways: Notch Signaling, Neurotrophin Signaling Pathway