Human Immunodeficiency Virus Vpx (HIV Vpx) (AA 1-112) antibody (Biotin)
Quick Overview for Human Immunodeficiency Virus Vpx (HIV Vpx) (AA 1-112) antibody (Biotin) (ABIN7156074)
Target
Reactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 1-112
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Purpose
- vpx Antibody, Biotin conjugated
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Purification
- Protein G purified
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Purity
- >95 %
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Immunogen
- Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-112AA)
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Isotype
- IgG
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anti-Human Immunodeficiency Virus Vpx (HIV Vpx) (AA 1-112) antibody
HIV Vpx Reactivity: Human Immunodeficiency Virus (HIV) ELISA, WB Host: Rabbit Polyclonal unconjugated
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Human Immunodeficiency Virus Vpx (HIV Vpx)
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Alternative Name
- HIV vpx
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Target Type
- Viral Protein
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Background
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Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).
Aliases: vpxProtein Vpx antibody, Viral protein X antibody, X ORF protein antibody
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UniProt
- P06939
Target
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