IL28RA antibody (AA 21-228)

Catalog No. ABIN7156606

Product Details anti-IL28RA Antibody

Target: IL28RA (Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA))

Binding Specificity: AA 21-228

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL28RA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Interferon lambda receptor 1 protein (21-228AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IL28RA

Target: IL28RA (Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA))

Alternative Name: IFNLR1 (IL28RA Products)

Synonyms: IFNLR1 antibody, IL28RA antibody, crf2/12 antibody, ifnlr antibody, il-28r1 antibody, il28ra antibody, licr2 antibody, ifnlr1 antibody, CRF2-12 antibody, Il28ra antibody, CRF2/12 antibody, IFNLR antibody, IL-28R1 antibody, LICR2 antibody, RGD1562689 antibody, interferon lambda receptor 1 antibody, interferon, lambda receptor 1 antibody, interferon, lambda receptor 1 L homeolog antibody, IFNLR1 antibody, ifnlr1 antibody, ifnlr1.L antibody, Ifnlr1 antibody

Background:

Background: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

Aliases: IFNLR1 antibody, IL28RA antibody, LICR2 antibody, Interferon lambda receptor 1 antibody, IFN-lambda receptor 1 antibody, IFN-lambda-R1 antibody, Cytokine receptor class-II member 12 antibody, Cytokine receptor family 2 member 12 antibody, CRF2-12 antibody, Interleukin-28 receptor subunit alpha antibody, IL-28 receptor subunit alpha antibody, IL-28R-alpha antibody, IL-28RA antibody, Likely interleukin or cytokine receptor 2 antibody, LICR2 antibody

UniProt: Q8IU57