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LRRK2 antibody (AA 2029-2275)

LRRK2 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7373744
  • Target See all LRRK2 Antibodies
    LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))
    Binding Specificity
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2029-2275
    Reactivity
    • 18
    • 8
    • 1
    Human
    Host
    • 15
    • 3
    Rabbit
    Clonality
    • 14
    • 4
    Polyclonal
    Conjugate
    • 15
    • 1
    • 1
    • 1
    This LRRK2 antibody is un-conjugated
    Application
    • 13
    • 8
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Leucine-rich repeat serine/threonine-protein kinase 2 protein (2029-2275AA)
    Isotype
    IgG
    Top Product
    Discover our top product LRRK2 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))
    Alternative Name
    LRRK2 (LRRK2 Products)
    Synonyms
    LRRK2 antibody, AURA17 antibody, DARDARIN antibody, PARK8 antibody, RIPK7 antibody, ROCO2 antibody, 4921513O20Rik antibody, 9330188B09Rik antibody, AW561911 antibody, D630001M17Rik antibody, Gm927 antibody, cI-46 antibody, leucine-rich repeat kinase 2 antibody, leucine rich repeat kinase 2 antibody, lrrk2 antibody, LRRK2 antibody, Lrrk2 antibody
    Background

    Background: Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH , and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.

    Aliases: augmented in rheumatoid arthritis 17 antibody, AURA17 antibody, Dardarin antibody, Leucine rich repeat kinase 2 antibody, leucine rich repeat serine threonine protein kinase 2 antibody, Leucine-rich repeat serine/threonine-protein kinase 2 antibody, LRRK 2 antibody, LRRK2 antibody, LRRK2_HUMAN antibody, PARK 8 antibody, PARK8 antibody, RIPK7 antibody, ROCO 2 antibody, ROCO2 antibody

    UniProt
    Q5S007
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
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