Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

NR1D2 antibody (AA 14-318)

NR1D2 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7161736
  • Target See all NR1D2 Antibodies
    NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))
    Binding Specificity
    • 15
    • 8
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 14-318
    Reactivity
    • 52
    • 9
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 49
    • 5
    Rabbit
    Clonality
    • 50
    • 4
    Polyclonal
    Conjugate
    • 26
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NR1D2 antibody is un-conjugated
    Application
    • 30
    • 22
    • 18
    • 13
    • 13
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human NR1D2 protein (14-318AA)
    Isotype
    IgG
    Top Product
    Discover our top product NR1D2 Primary Antibody
  • Application Notes
    Recommended dilution: WB:1:500-1:5000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    NR1D2 (Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))
    Alternative Name
    NR1D2 (NR1D2 Products)
    Synonyms
    BD73 antibody, EAR-1R antibody, RVR antibody, HZF-2 antibody, Rev-erb antibody, REV-ERBB antibody, NR1D2 antibody, rvr antibody, bd73 antibody, hzf2 antibody, ear-1r antibody, hs.37288 antibody, NR1D2-A antibody, Reverbbeta-A antibody, reverbb1 antibody, reverbb antibody, reverbb2 antibody, zgc:92019 antibody, nuclear receptor subfamily 1 group D member 2 antibody, nuclear receptor subfamily 1, group D, member 2 antibody, nuclear receptor subfamily 1, group D, member 2a antibody, nuclear receptor subfamily 1, group D, member 2b antibody, NR1D2 antibody, Nr1d2 antibody, nr1d2 antibody, nr1d2a antibody, nr1d2b antibody
    Background

    Background: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5\\\'-[A/G]GGTCA-3\\\' preceded by an A/T-rich 5\\\' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle.

    Aliases: Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R), NR1D2

    UniProt
    Q6NSM0
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway