NR2E1 antibody (AA 106-385)

Catalog No. ABIN7161905

Product Details anti-NR2E1 Antibody

Target: NR2E1 (Nuclear Receptor Subfamily 2, Group E, Member 1 (NR2E1))

Binding Specificity: AA 106-385

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR2E1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Nuclear receptor subfamily 2 group E member 1 protein (106-385AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NR2E1

Target: NR2E1 (Nuclear Receptor Subfamily 2, Group E, Member 1 (NR2E1))

Alternative Name: NR2E1 (NR2E1 Products)

Synonyms: NR2E1 antibody, TLL antibody, TLX antibody, XTLL antibody, Mtl1 antibody, Mtll antibody, Tlx antibody, fierce antibody, frc antibody, tailless antibody, fc30e03 antibody, fc39f12 antibody, wu:fc30e03 antibody, wu:fc39f12 antibody, zgc:100991 antibody, Xtll antibody, nr2e1-A antibody, tlx antibody, nuclear receptor subfamily 2 group E member 1 antibody, nuclear receptor subfamily 2, group E, member 1 antibody, nuclear receptor subfamily 2 group E member 1 S homeolog antibody, NR2E1 antibody, Nr2e1 antibody, nr2e1 antibody, nr2e1.S antibody

Background:

Background: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5\\\'-AAGGTCA-3\\\' in which the 5\\\' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells.

Aliases: hTll antibody, NR2E1 / Tailless antibody, nr2e1 antibody, NR2E1_HUMAN antibody, Nuclear receptor subfamily 2 group E member 1 antibody, Nuclear receptor TLX antibody, Orphan nuclear receptor NR2E1 antibody, Protein tailless homolog antibody, Tailless homolog antibody, Tll antibody, TLX antibody, XTLL antibody

UniProt: Q9Y466

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance