PIK3R2 antibody (Regulatory Subunit beta)

Catalog No. ABIN7163167

Product Details anti-PIK3R2 Antibody

Target: PIK3R2 (PI3K p85b) (Phosphoinositide 3 Kinase, p85 beta (PI3K p85b))

Binding Specificity: AA 75-125, Regulatory Subunit beta

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIK3R2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Phosphatidylinositol 3-kinase regulatory subunit beta protein (75-125AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PIK3R2

Target: PIK3R2 (PI3K p85b) (Phosphoinositide 3 Kinase, p85 beta (PI3K p85b))

Alternative Name: PIK3R2 (PI3K p85b Products)

Synonyms: MPPH antibody, P85B antibody, p85 antibody, p85-BETA antibody, pik3r2 antibody, MGC80449 antibody, p85beta antibody, phosphoinositide-3-kinase regulatory subunit 2 antibody, phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta) antibody, phosphoinositide-3-kinase, regulatory subunit 2 (beta) antibody, PIK3R2 antibody, pik3r2 antibody, Pik3r2 antibody

Background:

Background: Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).

Aliases: p85 antibody, p85 beta antibody, P85B antibody, P85B_HUMAN antibody, Phosphatidylinositol 3 kinase antibody, Phosphatidylinositol 3 kinase regulatory beta subunit antibody, Phosphatidylinositol 3 kinase regulatory subunit beta antibody, Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2 antibody, Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta) antibody, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta antibody, Phosphatidylinositol 3-kinase regulatory subunit beta antibody, Phosphoinositide 3 kinase regulatory subunit 2 (beta) antibody, Phosphoinositide 3 kinase regulatory subunit 2 antibody, Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta) antibody, Phosphoinositide 3 kinase regulatory subunit polypeptide 2 antibody, Phosphoinositide 3 kinase, regulatory subunit 2 (beta) antibody, Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta) antibody, PI3 kinase p85 beta subunit antibody, PI3 kinase p85 subunit beta antibody, PI3-kinase regulatory subunit beta antibody, PI3-kinase subunit p85-beta antibody, PI3K antibody, PI3K regulatory subunit beta antibody, PIK3R 2 antibody, PIK3R2 antibody, PtdIns 3 kinase p85 beta antibody, PtdIns-3-kinase regulatory subunit beta antibody, PtdIns-3-kinase regulatory subunit p85-beta antibody

UniProt: O00459

Pathways: VEGF Signaling, BCR Signaling