PSMB8 antibody (AA 176-276)

Catalog No. ABIN7164990

Product Details anti-PSMB8 Antibody

Target: PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))

Binding Specificity: AA 176-276

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMB8 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Proteasome subunit beta type-8 protein (176-276AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PSMB8

Target: PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))

Alternative Name: PSMB8 (PSMB8 Products)

Synonyms: ALDD antibody, D6S216 antibody, D6S216E antibody, JMP antibody, LMP7 antibody, NKJO antibody, PSMB5i antibody, RING10 antibody, ATP6V0D2 antibody, lmp7 antibody, prosome antibody, macropain antibody, Lmp-7 antibody, Lmp7 antibody, Ring10 antibody, proteasome subunit beta 8 antibody, proteasome subunit beta 8A antibody, proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) antibody, PSMB8 antibody, psmb8a antibody, Psmb8 antibody

Background:

Background: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH . The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.

Aliases: ALDD antibody, D6S216 antibody, D6S216E antibody, Large multifunctional peptidase 7 antibody, Large multifunctional protease 7 antibody, LMP 7 antibody, LMP7 antibody, Low molecular mass protein 7 antibody, Low molecular weight protein 7 antibody, Macropain subunit C13 antibody, MGC1491 antibody, Multicatalytic endopeptidase complex subunit C13 antibody, NKJO antibody, OTTHUMP00000062981 antibody, Protease component C13 antibody, Proteasome (prosome macropain) subunit beta type 8 antibody, Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) antibody, Proteasome beta 8 subunit antibody, Proteasome catalytic subunit 3i antibody, Proteasome component C13 antibody, Proteasome related gene 7 antibody, Proteasome subunit beta 5i antibody, Proteasome subunit beta 8 antibody, Proteasome subunit beta type 8 antibody, Proteasome subunit beta type antibody, Proteasome subunit beta type-8 antibody, Proteasome subunit beta-5i antibody, Proteasome subunit Y2 antibody, PSB8_HUMAN antibody, PSMB 8 antibody, PSMB5i antibody, PSMB8 antibody, Really interesting new gene 10 protein antibody, RING 10 antibody, RING10 antibody, Y2 antibody

UniProt: P28062

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA