LAMTOR1 antibody (AA 2-161) (HRP)

Catalog No. ABIN7167071

Product Details anti-LAMTOR1 Antibody (HRP)

Target: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Binding Specificity: AA 2-161

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAMTOR1 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ragulator complex protein LAMTOR1 protein (2-161AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for LAMTOR1

Target: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Alternative Name: LAMTOR1 (LAMTOR1 Products)

Synonyms: C11orf59 antibody, PDRO antibody, Ragulator1 antibody, p18 antibody, p27RF-Rho antibody, 2400001E08Rik antibody, Pdro antibody, C15H11orf59 antibody, c11orf59 antibody, flj20625 antibody, p27rf-rho antibody, pdro antibody, ragulator1 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 S homeolog antibody, LAMTOR1 antibody, Lamtor1 antibody, lamtor1.S antibody

Background:

Background: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

Aliases: C11orf59 antibody, LAMTOR1 antibody, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 antibody, Lipid raft adaptor protein p18 antibody, LTOR1_HUMAN antibody, p18 antibody, p27Kip1-releasing factor from RhoA antibody, p27RF-Rho antibody, PDRO antibody, PP7157 antibody, Protein associated with DRMs and endosomes antibody, Ragulator complex protein LAMTOR1 antibody, ragulator complex protein PDRO antibody, Ragulator1 antibody, RhoA activator C11orf59 antibody

UniProt: Q6IAA8