PTPRB antibody (AA 1758-1997)

Catalog No. ABIN7167501

Product Details anti-PTPRB Antibody

Target: PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))

Binding Specificity: AA 1758-1997

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPRB antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Receptor-type tyrosine-protein phosphatase beta protein (1758-1997AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PTPRB

Target: PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))

Alternative Name: PTPRB (PTPRB Products)

Synonyms: PTPRB antibody, HPTP-BETA antibody, HPTPB antibody, PTPB antibody, R-PTP-BETA antibody, VEPTP antibody, 3230402H02Rik antibody, C130094E24 antibody, Ptpz antibody, Rptpb antibody, VE-PTP antibody, Veptp antibody, protein tyrosine phosphatase, receptor type B antibody, receptor-type tyrosine-protein phosphatase beta antibody, protein tyrosine phosphatase, receptor type, B antibody, PTPRB antibody, LOC100380677 antibody, Ptprb antibody

Background:

Background: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

Aliases: HPTP BETA antibody, HPTPB antibody, Phosphacan receptor type B antibody, Protein tyrosine phosphatase receptor type B antibody, Protein-tyrosine phosphatase beta antibody, PTPB antibody, Ptprb antibody, PTPRB_HUMAN antibody, R PTP BETA antibody, R-PTP-beta antibody, Receptor-type tyrosine-protein phosphatase beta antibody, RPTPB antibody, Vascular endothelial protein tyrosine phosphatase antibody, VE-PTP antibody

UniProt: P23467