ARHGEF18 antibody (AA 159-551) (FITC)

Catalog No. ABIN7167976

This anti-ARHGEF18 antibody is a Rabbit Polyclonal antibody detecting ARHGEF18 in . Suitable for Human.

Quick Overview for ARHGEF18 antibody (AA 159-551) (FITC) (ABIN7167976)

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF18 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-ARHGEF18 Antibody (FITC)

Binding Specificity: AA 159-551

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Rho guanine nucleotide exchange factor 18 protein (159-551AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ARHGEF18

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Alternative Name: ARHGEF18

Background:

Background: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950).

Aliases: 114 kDa Rho specific guanine nucleotide exchange factor antibody, 114 kDa Rho-specific guanine nucleotide exchange factor antibody, ARHGEF 18 antibody, Arhgef18 antibody, ARHGI_HUMAN antibody, KIAA0521 antibody, MGC15913 antibody, p114 Rho GEF antibody, p114-Rho-GEF antibody, p114RhoGEF antibody, Rho guanine nucleotide exchange factor 18 antibody, Rho specific guanine nucleotide exchange factor p114 antibody, Rho/Rac guanine nucleotide exchange factor (GEF) 18 antibody, Rho/Rac guanine nucleotide exchange factor 18 antibody, SA RhoGEF antibody, SA-RhoGEF antibody, Septin associated RhoGEF antibody, Septin-associated RhoGEF antibody

UniProt: Q6ZSZ5

Pathways: Neurotrophin Signaling Pathway