DROSHA antibody (AA 1-100) (Biotin)

Catalog No. ABIN7168100

Product Details anti-DROSHA Antibody (Biotin)

Target: DROSHA (Drosha, Ribonuclease Type III (DROSHA))

Binding Specificity: AA 1-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DROSHA antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Antigen Affinity purified & Affinity purified

Immunogen: Recombinant Human Ribonuclease 3 protein (1-100AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DROSHA

Target: DROSHA (Drosha, Ribonuclease Type III (DROSHA))

Alternative Name: DROSHA (DROSHA Products)

Synonyms: im:7150667 antibody, zgc:158612 antibody, ETOHI2 antibody, HSA242976 antibody, RANSE3L antibody, RN3 antibody, RNASE3L antibody, RNASEN antibody, 1110013A17Rik antibody, AI874853 antibody, Etohi2 antibody, Rn3 antibody, Rnasen antibody, RGD1307626 antibody, ribonuclease type III, nuclear antibody, Ribonuclease 3 antibody, ribonuclease 3 antibody, drosha ribonuclease III antibody, drosha, ribonuclease type III antibody, rnasen antibody, Thicy_0885 antibody, Sinme_0866 antibody, Isova_2087 antibody, Sphch_0770 antibody, DROSHA antibody, Drosha antibody

Background:

Background: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3\' and 5\' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

Aliases: DROSHA antibody, Drosha double stranded RNA specific endoribonuclease antibody, Drosha ribonuclease type III antibody, Etohi2 antibody, HSA242976 antibody, Nuclear RNase III Drosha antibody, p241 antibody, Protein Drosha antibody, Putative protein p241 which interacts with transcription factor Sp1 antibody, Putative ribonuclease III antibody, RANSE3L antibody, Ribonuclease 3 antibody, Ribonuclease III antibody, Ribonuclease III nuclear antibody, Ribonuclease type III nuclear antibody, RibonucleaseIII antibody, RN 3 antibody, RN3 antibody, RNase 3 antibody, RNase III antibody, RNase3 antibody, RNASE3L antibody, RNaseIII antibody, RNASEN antibody, RNC_HUMAN antibody

UniProt: Q9NRR4

Pathways: Regulatory RNA Pathways