TRPV6 antibody (AA 620-764)

Catalog No. ABIN7172889

Product Details anti-TRPV6 Antibody

Target: TRPV6 (Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6))

Binding Specificity: AA 620-764

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPV6 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Transient receptor potential cation channel subfamily V member 6 protein (620-764AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRPV6

Target: TRPV6 (Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6))

Alternative Name: TRPV6 (TRPV6 Products)

Synonyms: ecac antibody, trpv5-6 antibody, TRPV6 antibody, trpv6 antibody, CaT antibody, ECaC antibody, ABP/ZF antibody, CAT1 antibody, CATL antibody, ECAC2 antibody, HSA277909 antibody, LP6728 antibody, ZFAB antibody, CAT antibody, CaT1 antibody, Cac antibody, Ecac2 antibody, Otrpc3 antibody, transient receptor potential cation channel, subfamily V, member 6 antibody, transient receptor potential cation channel subfamily V member 6 antibody, trpv6 antibody, TRPV6 antibody, Trpv6 antibody

Background:

Background: Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.

Aliases: ABP/ZF antibody, ABPZF antibody, Alu binding protein with zinc finger domain antibody, Calcium channel CaT1 antibody, Calcium transport protein 1 antibody, CaT L antibody, CaT Like antibody, CaT-L antibody, CaT-like antibody, CaT1 antibody, ecac antibody, ECaC2 antibody, Epithelial apical membrane calcium transporter/channel CaT1 antibody, Epithelial calcium channel 2 antibody, Epithelial calcium channel antibody, HSA277909 antibody, LP6728 antibody, MGC162545 antibody, NUDC antibody, Transient receptor potential cation channel subfamily V member 6 antibody, TrpV6 antibody, TRPV6_HUMAN antibody, ZFAB antibody

UniProt: Q9H1D0

Pathways: TCR Signaling