TNFRSF1B antibody (C-Term)

Catalog No. ABIN7180270

Product Details anti-TNFRSF1B Antibody

Target: TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFRSF1B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human TNF Receptor II.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IF:1:100-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TNFRSF1B

Target: TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))

Alternative Name: TNFRSF1B (TNFRSF1B Products)

Synonyms: CD120b antibody, TBPII antibody, TNF-R-II antibody, TNF-R75 antibody, TNFBR antibody, TNFR1B antibody, TNFR2 antibody, TNFR80 antibody, p75 antibody, p75TNFR antibody, TNF-RII/TNFRSF1B antibody, TNFR-II antibody, TNFRSF1B antibody, TNF-R2 antibody, TNF-alphaR2 antibody, TNFRII antibody, TNFalpha-R2 antibody, Tnfr-1 antibody, Tnfr2 antibody, rank antibody, zgc:163064 antibody, TNF receptor superfamily member 1B antibody, tumor necrosis factor receptor superfamily, member 1b antibody, tumor necrosis factor receptor superfamily, member 1B antibody, TNFRSF1B antibody, Tnfrsf1b antibody, tnfrsf1b antibody

Background:

Background: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Smith C.A., Science 248:1019-1023(1990).
Kohno T., Proc. Natl. Acad. Sci. U.S.A. 87:8331-8335(1990).
Beltinger C.P., Genomics 35:94-100(1996).

Aliases: CD120b antibody, p75 antibody, p75 TNF receptor antibody, p75TNFR antibody, p80 TNF alpha receptor antibody, p80 TNF-alpha receptor antibody, Soluble TNFR1B variant 1 antibody, TBP-2 antibody, TBPII antibody, TNF R II antibody, TNF R2 antibody, TNF R75 antibody, TNF-R2 antibody, TNF-RII antibody, TNFBR antibody, TNFR-II antibody, TNFR1B antibody, TNFR2 antibody, TNFR80 antibody, TNFRII antibody, Tnfrsf1b antibody, TNR1B_HUMAN antibody, Tumor necrosis factor beta receptor antibody, Tumor necrosis factor binding protein 2 antibody, Tumor necrosis factor receptor 2 antibody, Tumor necrosis factor receptor superfamily member 1B antibody, Tumor necrosis factor receptor type II antibody, Tumor necrosis factor-binding protein 2 antibody

UniProt: P20333

Pathways: NF-kappaB Signaling, Apoptosis, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Ubiquitin Proteasome Pathway