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ERN2 antibody

ERN2 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7190588
  • Target See all ERN2 Antibodies
    ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))
    Reactivity
    • 29
    • 19
    Human
    Host
    • 44
    • 1
    Rabbit
    Clonality
    • 45
    Polyclonal
    Conjugate
    • 18
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ERN2 antibody is un-conjugated
    Application
    • 32
    • 31
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    Antigen affinity purification
    Immunogen
    Synthetic peptide of Human ERN2
    Isotype
    IgG
    Top Product
    Discover our top product ERN2 Primary Antibody
  • Application Notes
    ELISA:1:2000-1:5000, IHC:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))
    Alternative Name
    ERN2 (ERN2 Products)
    Synonyms
    Ire1beta antibody, ire1b antibody, Ern1 antibody, Ire1 antibody, Ire1b antibody, IRE1-BETA antibody, IRE1b antibody, endoplasmic reticulum to nucleus signaling 2 antibody, endoplasmic reticulum (ER) to nucleus signalling 2 antibody, ERN2 antibody, ern2 antibody, Ern2 antibody
    Background

    Background: The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.

    Aliases: ERN2 antibody, IRE2Serine/threonine-protein kinase/endoribonuclease IRE2 antibody, Endoplasmic reticulum-to-nucleus signaling 2 antibody, Inositol-requiring protein 2 antibody, hIRE2p antibody, Ire1-beta antibody, IRE1b) [Includes: Serine/threonine-protein kinase antibody, EC 2.7.11.1), Endoribonuclease antibody, EC 3.1.26.-)] antibody

    UniProt
    Q76MJ5
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