ITPR2 antibody

Catalog No. ABIN7191144

Product Details anti-ITPR2 Antibody

Target: ITPR2 (Inositol 1,4,5-Trisphosphate Receptor, Type 2 (ITPR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITPR2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of Human ITPR2

Isotype: IgG

Application Details

Application Notes: ELISA:1:2000-1:10000, IHC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ITPR2

Target: ITPR2 (Inositol 1,4,5-Trisphosphate Receptor, Type 2 (ITPR2))

Alternative Name: ITPR2 (ITPR2 Products)

Synonyms: AI649341 antibody, InsP3R-2 antibody, InsP3R-5 antibody, Ip3r2 antibody, Itpr5 antibody, insP3R2 antibody, IP3R2 antibody, inositol 1,4,5-trisphosphate receptor type 2 antibody, inositol 1,4,5-triphosphate receptor 2 antibody, inositol 1,4,5-trisphosphate receptor, type 2 antibody, ITPR2 antibody, Itpr2 antibody

Background:

Background: Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.

Aliases: 4 antibody, 5-trisphosphate receptor antibody, Inositol 1 4 5 trisphosphate receptor type 2 antibody, Inositol 1,4,5-trisphosphate receptor type 2 antibody, Inositol 145 trisphosphate receptor type 2 antibody, InsP3 R2 antibody, InsP3R2 antibody, IP3 R2 antibody, IP3 receptor antibody, IP3 receptor isoform 2 antibody, IP3R 2 antibody, IP3R2 antibody, ITPR 2 antibody, Itpr2 antibody, ITPR2_HUMAN antibody, Type 2 inositol 1 4 5 trisphosphate receptor antibody, Type 2 inositol 1 antibody, Type 2 inositol 145 trisphosphate receptor antibody, Type 2 InsP3 receptor antibody

UniProt: Q14571

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma