IFNA antibody (AA 101-189)

Catalog No. ABIN717131

Product Details anti-IFNA Antibody

Target: IFNA (Interferon alpha (IFNA))

Binding Specificity: AA 101-189

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFNA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody will detect Human IFN-Alpha subtypes 2,4,5,6,7,8,10,14,16,17 and has lower affinity for IFNA1/13. This antibody will detect Mouse IFN-Alpha subtypes 1,2,5,7,12,13,14,16

Cross-Reactivity: Mouse

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IFNA4

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for IFNA

Target: IFNA (Interferon alpha (IFNA))

Alternative Name: IFN-Alpha (IFNA Products)

Synonyms: IFN-alphaO antibody, IFN-ALPHA-1 antibody, IFN1@ antibody, Ifa antibody, Ifa8 antibody, interferon alpha 16 antibody, interferon, alpha 1 antibody, interferon alpha antibody, interferon-alpha antibody, IFNA16 antibody, IFNA1 antibody, Ifna antibody, IFNA antibody

Background:

Synonyms: IFNA, IFN-a, IFN-_, Interferon alpha, Interferon-alpha, IFNA2, IFNA4, IFNA6, IFNA7, IFNA8, IFNA10, IFNA16, IFNA17, IFNA5, IFNA21, IFNA14, IFNA1, IFNA13, Pan Interferon alpha

Background: Interferon-_ (IFN-_, also known as IFN-alpha, IFN-a, IFNA and Interferon-alpha) is a type I interferon and exists as 13 subtypes: IFN-_ 1, 2, 4, 5, 6, 7, 8, 10, 13, 14, 16, 17 and 21. They are mainly produced by virus-infected cells after sensing the presence of danger signals such as viral DNA or RNA. The binding of IFN-_ to its receptor initiates an anti-viral response, but also anti-tumor effects have been shown. A key producer of type I interferons is the plasmacytoid dendritic cell.

Gene ID: 3441

UniProt: P05014

Pathways: JAK-STAT Signaling, TLR Signaling, Hepatitis C, Inflammasome