CDKN2C antibody (AA 1-168)

Catalog No. ABIN7266610

Product Details anti-CDKN2C Antibody

Target: CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C))

Binding Specificity: AA 1-168

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKN2C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purpose: [KO Validated] CDKN2C/p18-INK4C Rabbit pAb

Sequence: MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP EIARRLLLRG ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED NEGNLPLHLA AKEGHLRVVE FLVKHTASNV GHRNHKGDTA CDLARLYGRN EVVSLMQANG AGGATNLQ

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Grade: KO Validated

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human CDKN2C/p18-INK4C (NP_523240.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CDKN2C

Target: CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) (CDKN2C))

Alternative Name: CDKN2C (CDKN2C Products)

Synonyms: CDKN2C antibody, p18 antibody, ink4c antibody, p18-ink4c antibody, INK4C antibody, p18-INK4C antibody, C77269 antibody, INK4c antibody, INK4d antibody, p18INK4c antibody, cyclin dependent kinase inhibitor 2C antibody, cyclin-dependent kinase inhibitor 2C antibody, cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) antibody, CDKN2C antibody, cdkn2c antibody, Cdkn2c antibody

Background: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.,CDKN2C,INK4C,p18,p18-INK4C,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,G1/S Checkpoint,CDKN2C

Molecular Weight: 18kDa

Gene ID: 1031

UniProt: P42773

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases