FGL1 antibody

Catalog No. ABIN7267179

Product Details anti-FGL1 Antibody

Target: FGL1 (Fibrinogen-Like 1 (FGL1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This FGL1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: FGL1 Rabbit mAb

Cross-Reactivity: Human

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant protein of human FGL-1 Full length.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.09 % sodium azide,50 % glycerol, pH 7.4.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FGL1

Target: FGL1 (Fibrinogen-Like 1 (FGL1))

Alternative Name: FGL1 (FGL1 Products)

Synonyms: MGC84748 antibody, FGL1 antibody, DKFZp470A2333 antibody, Frep1 antibody, Lfire1 antibody, HFREP1 antibody, HP-041 antibody, LFIRE-1 antibody, LFIRE1 antibody, Mfire1 antibody, fibrinogen like 1 L homeolog antibody, fibrinogen like 1 antibody, fibrinogen-like 1 antibody, fibrinogen-like protein 1 antibody, fgl1.L antibody, FGL1 antibody, Fgl1 antibody

Background: Fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. The FGL1-LAG-3 pathway maybe an important immune evasion mechanism and could contribute to current cancer immunotherapy efforts for several reasons. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner. FGL1 is highly produced by human cancer cells, and elevated FGL1 in the plasma of cancer patients is associated with a poor prognosis and resistance to anti-PD-1/B7-H1 therapy,FGL1,HFREP1,HP-041,LFIRE-1,LFIRE1,Cardiovascular,Blood,Coagulation,Serum Proteins,FGL1

Molecular Weight: 36kDa

Gene ID: 2267

UniProt: Q08830