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KLHDC2 antibody (AA 1-240)

KLHDC2 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7268073
  • Target See all KLHDC2 Antibodies
    KLHDC2 (Kelch Domain Containing 2 (KLHDC2))
    Binding Specificity
    • 9
    • 8
    • 6
    AA 1-240
    Reactivity
    • 24
    • 11
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 25
    Rabbit
    Clonality
    • 25
    Polyclonal
    Conjugate
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KLHDC2 antibody is un-conjugated
    Application
    • 18
    • 13
    Western Blotting (WB)
    Purpose
    KLHDC2 Rabbit pAb
    Sequence
    MADGNEDLRA DDLPGPAFES YESMELACPA ERSGHVAVSD GRHMFVWGGY KSNQVRGLYD FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD RVLYLFGGHH SRGNTNKFYM LDSRSTDRVL QWERIDCQGI PPSSKDKLGV WVYKNKLIFF GGYGYLPEDK VLGTFEFDET SFWNSSHPRG WNDHVHILDT ETFTWSQPIT TGKAPSPRAA HACATVGNRG FVFGGRYRDA
    Cross-Reactivity
    Human
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human KLHDC2 (NP_055130.1).
    Isotype
    IgG
    Top Product
    Discover our top product KLHDC2 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    KLHDC2 (Kelch Domain Containing 2 (KLHDC2))
    Alternative Name
    KLHDC2 (KLHDC2 Products)
    Synonyms
    MGC82652 antibody, HCLP-1 antibody, HCLP1 antibody, LCP antibody, 2310022K15Rik antibody, D12Ertd522e antibody, kelch domain containing 2 L homeolog antibody, kelch domain containing 2 antibody, klhdc2.L antibody, KLHDC2 antibody, Klhdc2 antibody
    Background
    Substrate-recognition component of a Cul2-RING (CRL2 E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC2 complex specifically recognizes proteins with a diglycine (Gly-Gly at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC2 complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine. The CRL2(KLHDC2 complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation. May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding.,KLHDC2,HCLP-1,HCLP1,LCP,Epigenetics & Nuclear Signaling,KLHDC2
    Molecular Weight
    28kDa/46kDa
    Gene ID
    23588
    UniProt
    Q9Y2U9
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