OTUD7B antibody (AA 530-700)

Catalog No. ABIN7269125

Product Details anti-OTUD7B Antibody

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Binding Specificity: AA 530-700

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTUD7B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purpose: OTUD7B Rabbit pAb

Sequence: SKPGGVGTGL GGSSGTETLE KKKKNSLKSW KGGKEEAAGD GPVSEKPPAE SVGNGGSKYS QEVMQSLSIL RTAMQGEGKF IFVGTLKMGH RHQYQEEMIQ RYLSDAEERF LAEQKQKEAE RKIMNGGIGG GPPPAKKPEP DAREEQPTGP PAESRAMAFS TGYPGDFTIP R

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 530-700 of human OTUD7B (NP_064590.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for OTUD7B

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Alternative Name: OTUD7B (OTUD7B Products)

Synonyms: OTUD7B antibody, ZA20D1 antibody, za20d1 antibody, zgc:152772 antibody, cezanne antibody, CEZANNE antibody, 2900060B22Rik antibody, 4930463P07Rik antibody, AI462125 antibody, Trabid2 antibody, Za20d1 antibody, RGD1308111 antibody, OTU deubiquitinase 7B antibody, OTU domain containing 7B antibody, OTUD7B antibody, otud7b antibody, Otud7b antibody

Background: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro, however the physiological significance of these data are unsure. Hydrolyzes both linear and branched forms of polyubiquitin.,OTUD7B,CEZANNE,ZA20D1,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,OTUD7B

Molecular Weight: 88kDa/92kDa

Gene ID: 56957

UniProt: Q6GQQ9