Research Grade
Reactivity: Human
Host: Mouse
Monoclonal
unconjugated
Recombinant Antibody
Restrictions
For Research Use only
Buffer
PBS pH 7.5
Storage
-80 °C
Storage Comment
store at -80°C
Target
MS4A1 (Ibritumomab Biosimilar)
Target Type
Biosimilar
Background
Ibritumomab is a monoclonal antibody directed against the CD20 antigen found on pre-B and mature B lymphocytes (normal and malignant). Ibritumomab binding induces apoptosis in B lymphocytes in vitro. It is combined with the chelator tiuxetan, which acts as a specific chelation site for Yttrium-90 (Y-90). The monoclonal antibody acts as a delivery system to direct the radioactive isotope to the targeted cells, however, binding has been observed in lymphoid cells throughout the body and in lymphoid nodules in organs such as the large and small intestines. beta-emission induces cellular damage through the formation of free radicals (in both target cells and surrounding cells).