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ID4 antibody (AA 61-160)

ID4 Reactivity: Human ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN719696
  • Target See all ID4 Antibodies
    ID4 (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4))
    Binding Specificity
    • 14
    • 14
    • 13
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 61-160
    Reactivity
    • 62
    • 31
    • 19
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 56
    • 6
    Rabbit
    Clonality
    • 59
    • 3
    Polyclonal
    Conjugate
    • 27
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This ID4 antibody is un-conjugated
    Application
    • 35
    • 28
    • 19
    • 12
    • 12
    • 12
    • 6
    • 2
    • 2
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat,Dog,Pig
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ID4
    Isotype
    IgG
    Top Product
    Discover our top product ID4 Primary Antibody
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    ID4 (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4))
    Alternative Name
    ID4 (ID4 Products)
    Synonyms
    Idb4 antibody, bHLHb27 antibody, cb547 antibody, fb77d04 antibody, sb:cb547 antibody, wu:fb77d04 antibody, zgc:123214 antibody, bhlhb27 antibody, id4 antibody, id4a antibody, idb4 antibody, IDB4 antibody, inhibitor of DNA binding 4 antibody, inhibitor of DNA binding 4, HLH protein antibody, inhibitor of DNA binding 4, HLH protein S homeolog antibody, Id4 antibody, id4 antibody, id4.S antibody, ID4 antibody
    Background

    Synonyms: bHLHb27, Class B basic helix-loop-helix protein 27, DNA binding protein inhibitor ID 4, DNA binding protein inhibitor ID4, DNA-binding protein inhibitor ID-4, ID 4, Id4, ID4_HUMAN, IDB4, Inhibitor of DNA binding 4, Inhibitor of DNA binding 4 dominant negative helix loop helix protein.

    Background: Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1 (13), Id2 (4), Id3 and Id4 (5). They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins (15). Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.

    Gene ID
    3400
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