KCNN4 antibody (AA 325-427)
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- Target See all KCNN4 Antibodies
- KCNN4 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4))
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Binding Specificity
- AA 325-427
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Reactivity
- Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This KCNN4 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Human, Rat
- Predicted Reactivity
- Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human KCNN4
- Isotype
- IgG
- Top Product
- Discover our top product KCNN4 Primary Antibody
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels." in: Frontiers in cellular neuroscience, Vol. 12, pp. 115, (2018) (PubMed).
: "Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells." in: PLoS ONE, Vol. 11, Issue 4, pp. e0154471, (2016) (PubMed).
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Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels." in: Frontiers in cellular neuroscience, Vol. 12, pp. 115, (2018) (PubMed).
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- Target
- KCNN4 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4))
- Alternative Name
- KCNN4 (KCNN4 Products)
- Background
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Synonyms: IK1, SK4, KCA4, hSK4, IKCA1, hKCa4, KCa3.1, hIKCa1, Intermediate conductance calcium-activated potassium channel protein 4, SKCa 4, SKCa4, Putative Gardos channel, KCNN4
Background: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
- Gene ID
- 3783
- UniProt
- O15554
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