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KLRK1 antibody (AA 121-219)

KLRK1 Reactivity: Mouse WB, FACS, ELISA, IHC (fro), IF (cc), IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN730078
  • Target See all KLRK1 Antibodies
    KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
    Binding Specificity
    • 15
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 121-219
    Reactivity
    • 54
    • 31
    • 8
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 53
    • 17
    • 3
    • 2
    • 2
    • 1
    Rabbit
    Clonality
    • 52
    • 24
    • 2
    Polyclonal
    Conjugate
    • 33
    • 9
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KLRK1 antibody is un-conjugated
    Application
    • 44
    • 42
    • 14
    • 14
    • 13
    • 12
    • 11
    • 10
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Mouse
    Predicted Reactivity
    Human,Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from rat KLRK1
    Isotype
    IgG
    Top Product
    Discover our top product KLRK1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Mozer-Lisewska, Mania, Kowala-Piaskowska, Kluk, Samara, Pauli, ?eromski: "Detection and significance of cytotoxic cell subsets in biopsies of HCV-infected human livers." in: Archivum immunologiae et therapiae experimentalis, Vol. 62, Issue 2, pp. 153-60, (2014) (PubMed).

    Onishi, Kiyota, Koya, Tanaka, Umebayashi, Katano, Morisaki: "Random migration contributes to cytotoxicity of activated CD8+ T-lymphocytes but not NK cells." in: Anticancer research, Vol. 34, Issue 8, pp. 3947-56, (2014) (PubMed).

    Ruck, Bittner, Gross, Breuer, Albrecht, Korr, Göbel, Pankratz, Henschel, Schwab, Staszewski, Prinz, Kuhlmann, Meuth, Wiendl: "CD4+NKG2D+ T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation." in: PLoS ONE, Vol. 8, Issue 11, pp. e81455, (2013) (PubMed).

  • Target
    KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
    Alternative Name
    NKG2D (KLRK1 Products)
    Synonyms
    KLRK1 antibody, NKG2D antibody, CD314 antibody, D12S2489E antibody, KLR antibody, NKG2-D antibody, D6H12S2489E antibody, Nkg2d antibody, Nkrp2 antibody, killer cell lectin like receptor K1 antibody, killer cell lectin-like receptor subfamily K, member 1 antibody, NKG2D protein antibody, KLRK1 antibody, Klrk1 antibody, NKG2D antibody
    Background

    Synonyms: NKG2D, Nkrp2, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NK lectin-like receptor, NKLLR, NKG2-D-activating NK receptor, NKR-P2, CD314, Klrk1

    Background: Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.

    Gene ID
    24934
    UniProt
    O70215
    Pathways
    Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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